2465-2470 A12-33.fm

A Phase I Study of Cixutumumab (IMC-A12) in Combination with Temsirolimus (CCI-779) in Children with Recurrent Solid Tumors: A Children's Oncology Group Phase I Consortium Report.

PURPOSE To determine the MTD, dose-limiting toxicities (DLT), pharmacokinetics, and biologic effects of cixutumumab administered in combination with temsirolimus to children with refractory solid tumors. EXPERIMENTAL DESIGN Cixutumumab and temsirolimus were administered intravenously once every 7 days in 28-day cycles. Pharmacokinetic and biology studies, including assessment of mTOR downstre...

شیوه خاص حافظ

Ability of foot-and-mouth disease virus to form plaques in cell culture is associated with suppression of alpha/beta interferon.

A genetic variant of foot-and-mouth disease virus lacking the leader proteinase coding region (A12-LLV2) is attenuated in both cattle and swine and, in contrast to wild-type virus (A12-IC), does not spread from the initial site of infection after aerosol exposure of bovines. We have identified secondary cells from susceptible animals, i.e., bovine, ovine, and porcine animals, in which infection...

Melanoma antigen A12 regulates cell cycle via tumor suppressor p21 expression

Melanoma-associated antigen family A (MAGE-A) is a family of cancer/testis antigens that are expressed in malignant tumors but not in normal tissues other than the testes. MAGE-A12 is a MAGE-A family gene whose tumorigenic function in cancer cells remains unclear. Searches of the Oncomine and NextBio databases revealed that malignant tumors show up-regulation of MAGE-A12 mRNA relative to corres...

استخراج انرژی الکتریکی از نوسانات مکانیکی تصادفی توسط سامانه های الکترومکانیکی خطی و غیر خطی: مقایسه نوفه های مختلف

We investigate harvesting electrical energy from Gaussian white, Gaussian colored, telegraph and random phase-random amplitude (RARP) noises, using linear and nonlinear electromechanical systems. We show that the output power of the linear system with one or two degrees of freedom, is maximum for the Gaussian white noise. The response of the system with two degrees of freedom is widened in a la...